Expert Videos

Module 1: Understanding Alzheimer's Disease

What is Alzheimer's disease?
Richard Isaacson, MD, explains what Alzheimer's disease is, including who gets it and at what age. He describes what a neurodegenerative disease such as Alzheimer's does in the brain, the difference between Alzheimer's disease and different types of dementia, and how common each of these conditions is as a cause of cognitive decline with aging. Dr. Isaacson also explains the difference between pharmacologic and non-pharmacologic treatments for Alzheimer's disease.
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What are the symptoms of Alzheimer's disease?
In this video, Alzheimer's disease expert Dr. Richard Isaacson describes the symptoms of the condition. He discusses short-term memory loss and other effects on cognitive function, which includes thinking, memory, and other abilities. Dr. Isaacson also discusses why Alzheimer's is a neuropsychiatric disorder, meaning that it affects the behavior of people who have it, as well as their memory and thinking processes and other brain functions. Finally, Dr. Isaacson highlights the important difference between mild cognitive impairment due to Alzheimer's disease and full-blown Alzheimer's dementia.
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What are the causes and risk factors of Alzheimer's disease?
Richard Isaacson, MD, an Alzheimer's disease expert from Weill Cornell Medicine and NewYork-Presbyterian Hospital, talks about what we know about the causes of Alzheimer's disease. Risk factors, or things that raise the risk of developing Alzheimer's, are an important area of research. Dr. Isaacson discusses how genetics, genetic testing and the APOE4 variant play a role in developing Alzheimer's disease. He also discusses how lifestyle factors are involved, from a brain-healthy diet to the roles of sleep, stress, and sugar in developing Alzheimer's disease. Finally, Dr. Isaacson makes some intriguing suggestions for lifestyle changes and activities that may be beneficial in lowering the risk of Alzheimer's disease.
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Is Alzheimer's disease hereditary? Is there a genetic component?
Dr. Richard Isaacson, director of the Alzheimer's Prevention Clinic at Weill Cornell Medicine and NewYork-Presbyterian Hospital, discusses the complex role of heredity in Alzheimer's disease. He explains how interactions between genes and the environment, known as epigenetics, influences who will develop a certain disease such as Alzheimer's. Dr. Isaacson also discusses the importance of variants of the APOE gene, the most common susceptibility gene associated with Alzheimer's disease, and ways to avoid known risks if you have this gene. This video also explains the role of genes in a type of Alzheimer's disease called early-onset Alzheimer's disease.
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How is Alzheimer's disease diagnosed?
Richard Isaacson, MD, an expert on Alzheimer's disease, describes the steps necessary to diagnose this condition. It is important to see a medical doctor for diagnosis if you have progressive short-term memory loss. Dr. Isaacson discusses the importance of knowing your family medical history, having appropriate blood tests to look for other conditions besides Alzheimer's disease, and which imaging tests are usually done to examine the brain for signs of Alzheimer's. He also talks about which tests may be the most useful to diagnose Alzheimer's disease in the future.
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What are the stages of Alzheimer's disease?
Richard Isaacson, MD, directs the Alzheimer's Prevention Clinic at Weill Cornell Medicine and NewYork-Presbyterian Hospital. In this video, he explains the stages of progressive brain decline in Alzheimer's disease from pre-clinical through mild cognitive impairment (MCI) to Alzheimer's dementia, including its phases. He discusses how cognitive function changes at each stage and how the stage of Alzheimer's disease someone has will determine the care and treatment they need.
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Module 2: Managing and Treating Alzheimer's Disease

What medications are used to treat Alzheimer's disease?
In this video, Alzheimer's disease expert Richard Isaacson, MD, discusses the four US Food and Drug Administration-approved prescription medications that are currently used to treat people with Alzheimer's disease. He describes both acetylcholinesterase inhibitors and memantine and discusses the stage of Alzheimer's when they may be given. Dr. Isaacson also talks about how these medications affect progressive brain decline, how much improvement patients and caregivers can expect, possible side effects, and the hope for new medications from ongoing research into Alzheimer's disease.
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What non-drug treatments are used for Alzheimer's disease?
Dr. Richard Isaacson, director of the Alzheimer's Prevention Clinic at Weill Cornell Medicine and NewYork-Presbyterian Hospital, talks about ways to reduce the effect of vascular (blood vessel) risk factors and slow the cognitive decline of Alzheimer's disease. He describes which other health conditions should be controlled for better clinical outcomes, as well as the role of the Mediterranean diet and how sleep, exercise, stress, and support for the person with Alzheimer's disease and those who care for them can all make a difference in coping with symptoms and improving quality of life with Alzheimer's.
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How can I help my loved one cope with symptoms and improve quality of life?
Richard Isaacson, MD, a leading expert on Alzheimer's disease, discusses the importance of education and awareness for caregivers and family members of people living with Alzheimer's disease. He recommends specific resources for information and help, including how to locate a social worker specializing in Alzheimer's disease care and support. Dr. Isaacson talks about the critical roles that psychological support and respite care play in being an effective caregiver, and the importance of information for the entire family of someone living with Alzheimer's.
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Can Alzheimer's disease be cured? Can it be prevented?
Is it possible to prevent or even cure Alzheimer's disease? Dr. Richard Isaacson, MD, Director of the Alzheimer's Prevention Clinic at Weill Cornell Medicine and NewYork-Presbyterian Hospital, talks about how many cases of Alzheimer's disease may be preventable with healthy life changes and consistent, effective treatment for several chronic health conditions, such as diabetes. While Alzheimer's disease cannot yet be cured, maintaining the best health possible may reduce your risk for mild cognitive impairment.
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What new treatments are in development for Alzheimer's disease?
Richard Isaacson, MD, a leading expert on Alzheimer's disease, reports that there are dozens of clinical trials, or research studies involving human volunteers, studying new medications for Alzheimer's disease. These include studies of drugs that attack the amyloid protein that builds up in the brain in Alzheimer's, and studies of drugs that attack other proteins and brain pathologies. Dr. Isaacson also discusses the role for lifestyle changes and treatment of other chronic conditions in managing Alzheimer's disease in the future.
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Jointly provided by the Annenberg Center for Health Sciences at Eisenhower and Prime Medic Inc., in collaboration with Postgraduate Institute for Medicine.

This activity is supported by an independent educational grant from Biogen Idec.

This website is part of the Animated Patient™ series developed by Prime Medic Inc., to provide highly visual formats of learning for patients to improve their understanding, make informed decisions, and partner with their healthcare professionals for optimal outcomes.